Diluting Diphenhydramine

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asked 3 years ago

The Benadryl Medication Reference states "Benadryl given IV should be diluted with 9 ml of Normal Saline prior to administration" yet the ALS protocol makes no mention of diluting the medication like it does for Gravol. Which is the correct way to administer Benadryl IV?

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answered 3 years ago

DiphenHYDRAMINE (Benadryl) IV ADMINISTRATION - Administer undiluted or diluted in 10 mL with NS. Give at a maximum rate of 25 mg/min.
Reference:
2021 The Ottawa Hospital Parenteral Drug Therapy Manual, Forty-Second Edition